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Single Molecule Biophysics

Content About: Single Molecule Biophysics

Published: 05/22/2014 - 9:11am Type of Content: Article-Research Highlight

Biomolecules may not always behave the same way in test tubes as they do in living cells, a fact underscored by important new work by former research associate Nick Dupuis, graduate student Erik Holmstrom, and Fellow David Nesbitt. The researchers found that under crowded conditions that begin to mimic those found in cells, single RNA molecules folded 35 times faster than in the dilute...

Published: 04/17/2014 - 10:33am Type of Content: Article-Research Highlight

Graduate student Erik Holmstrom and Fellow David Nesbitt have applied their laboratory research on the rates of RNA folding and unfolding to the medically important enzyme telomerase. Telomerase employs both protein and RNA components to lengthen chromosomes, which are shortened every time they are copied.

If one short piece of the RNA in telomerase is folded into an organized structure...

Published: 10/19/2012 - 9:34am Type of Content: People - Faculty & Research Groups
Published: 05/06/2013 - 12:27pm Type of Content: Biblio
Published: 11/14/2013 - 2:45pm Type of Content: Biblio
Published: 05/06/2013 - 12:43pm Type of Content: Biblio
Published: 02/28/2013 - 3:48pm Type of Content: Research Areas

The Ralph Jimenez group specializes in molecular biophysics, a relatively new field that employs concepts and techniques from physics, chemistry, and biology to elucidate the behaviors of biomolecules found in nature. The group’s eclectic research topics include (1) studies of the elastic properties of single cells, (2) the characterization of cellular fluorescent proteins, (3) investigations...

Published: 05/06/2013 - 12:33pm Type of Content: Biblio
Published: 05/06/2013 - 12:54pm Type of Content: Biblio
Published: 03/04/2013 - 2:48pm Type of Content: Research Areas

Single-Molecule Studies of DNA, RNA, and Protein

The study of single molecules of DNA, RNA, and protein is revolutionizing biophysics. To investigate the structure and function of selected biomolecules in all three categories, the Thomas Perkins group has developed and is using precision single-molecule biophysics techniques such as atomic force microscopy (AFM), single-molecule force...