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Molecular Biophysics

Content About: Molecular Biophysics

Published: 11/03/2017 - 1:02pm Type of Content: Article-Research Highlight

The actors are molecules. The plot, broken molecular bonds. JILA Fellow Ralph Jimenez and a team of detector experts at the National Institute of Standards and Technology (NIST) are working together to make X-ray movies of a molecular drama.

The team at NIST built a microcalorimeter X-ray spectrometer capable of performing time-resolved spectroscopy; in other words: a camera to film...

Published: 07/21/2017 - 2:56pm Type of Content: Article-Research Highlight

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision...

Published: 03/02/2017 - 1:45pm Type of Content: Article-Research Highlight

The Perkins group continues to extend the performance of its unique Atomic Force Microscope (AFM) technology, revealing for the first time a dozen new short-lived intermediate states in the folding and unfolding of a membrane protein that controls the exchange of chemicals and ions into and out of living cells. Measuring the energetics and dynamics of membrane proteins is crucial to...

Published: 10/31/2016 - 7:58am Type of Content: Article-Research Highlight

Far-red fluorescent light emitted from proteins could one day illuminate the inner workings of life. But before that happens, scientists like Fellow Ralph Jimenez must figure out how fluorescent proteins’ light-emitting structures work. As part of this effort, Jimenez wants to answer a simple question: How do we design red fluorescent proteins to emit longer-wavelength, or redder, light?

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Published: 05/11/2015 - 11:20am Type of Content: Article-Research Highlight

A wildly successful JILA (Nesbitt Group)-NIH collaboration is opening the door to studies of RNA behavior, including binding, folding and other factors that affect structural changes of RNA from living organisms. Such structural changes determine RNA enzymatic functions, including the regulation of genetic information.

Yun-Xing Wang of the National Institutes of Health (NIH) and his...

Published: 01/20/2015 - 9:09am Type of Content: Article-Research Highlight

Because red fluorescent proteins are important tools for cellular imaging, the Jimenez group is working to improve them to further biophysics research. The group’s quest for a better red-fluorescent protein began with a computer simulation of a protein called mCherry that fluoresces red light after laser illumination. The simulation identified a floppy (i.e., less stable) portion of the...

Published: 08/17/2012 - 2:26pm Type of Content: Article-Research Highlight

The Nesbitt group has been investigating RNA folding since the early 2000s. The group’s goal has been to gain a detailed understanding of the relationship between structure and function in this important biomolecule. One challenge has been figuring out how unfolded RNA molecules assume the proper three-dimensional (3D) shape to perform their biological activities. To accomplish this, the...

Published: 10/18/2011 - 6:00pm Type of Content: Article-Research Highlight

Graduate student Jennifer Lubbeck (Jimenez Group) spent the summer of 2011 doing research in the Molecular Spectroscopy Laboratory at the RIKEN Institute in Wako, Japan (near Tokyo). Her host's group included 16 postdocs and four graduate students (Figure 1). The group was under the direction of Chief Scientist Tahei Tahara. However, Lubbeck actually worked directly with just five other young...

Published: 03/02/2017 - 1:40pm Type of Content: Biblio
Published: 03/15/2013 - 12:06pm Type of Content: Biblio
Published: 04/29/2015 - 1:42pm Type of Content: Biblio
Published: 04/22/2015 - 1:39pm Type of Content: Biblio
Published: 04/11/2014 - 7:57am Type of Content: Biblio
Published: 10/18/2012 - 2:46pm Type of Content: People - Faculty & Research Groups