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Biological Force Standards

Content About: Biological Force Standards

Published: 01/09/2013 - 10:19am Type of Content: Article-Research Highlight

Gold glitters because it is highly reflective, a quality once considered important for precision measurements made with gold-coated probes in atomic force microscopy (AFM). In reality, the usual gold coating on AFM probes is a major cause of force instability and measurement imprecision, according to research done by the Perkins group. The group has shown that gold-coated probes are a...

Published: 04/20/2011 - 6:00pm Type of Content: Article-Research Highlight

JILA experiment shows nicks and free ends are not required for DNA overstretching

In science, it can be fun and interesting to upend conventional wisdom. A good example is what just happened to a widely accepted explanation for overstretching of double-stranded DNA (dsDNA). Overstretching occurs suddenly when researchers add a tiny increment of force to dsDNA that is already...

Published: 11/23/2010 - 5:00pm Type of Content: Article-Research Highlight

Atomic force microscopy (AFM) just got a whole lot more efficient for studying proteins and other biomolecules. Graduate student Allison Churnside, former research associate Gavin King, and Fellow Tom Perkins recently used a laser to detect the position of sparsely distributed biomolecules on a glass cover slip. Since the same laser is also used to locate the AFM tip, it is now possible to...

Published: 01/16/2014 - 11:22am Type of Content: Biblio
Published: 03/04/2013 - 2:50pm Type of Content: Research Areas

The Tom Perkins group investigates biological molecules as force standards at the pico-Newton scale (10-12 N). The forces applied by Atomic Force Microscopes (AFMs) and optical traps cannot be directly linked to an internationally accepted force standard (i.e., SI traceable) over the force range from pico-Newtons (10-12 N) to nano-Newtons (10-9 N). For AFM applications, SI traceability...

Published: 03/25/2013 - 3:33pm Type of Content: Biblio

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