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Ralph Jimenez

Content About: Ralph Jimenez

Published: 10/31/2016 - 7:58am Type of Content: Article-Research Highlight

Far-red fluorescent light emitted from proteins could one day illuminate the inner workings of life. But before that happens, scientists like Fellow Ralph Jimenez must figure out how fluorescent proteins’ light-emitting structures work. As part of this effort, Jimenez wants to answer a simple question: How do we design red fluorescent proteins to emit longer-wavelength, or redder, light?

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Published: 01/20/2015 - 9:09am Type of Content: Article-Research Highlight

Because red fluorescent proteins are important tools for cellular imaging, the Jimenez group is working to improve them to further biophysics research. The group’s quest for a better red-fluorescent protein began with a computer simulation of a protein called mCherry that fluoresces red light after laser illumination. The simulation identified a floppy (i.e., less stable) portion of the...

Published: 10/18/2011 - 6:00pm Type of Content: Article-Research Highlight

Graduate student Jennifer Lubbeck (Jimenez Group) spent the summer of 2011 doing research in the Molecular Spectroscopy Laboratory at the RIKEN Institute in Wako, Japan (near Tokyo). Her host's group included 16 postdocs and four graduate students (Figure 1). The group was under the direction of Chief Scientist Tahei Tahara. However, Lubbeck actually worked directly with just five other young...

Published: 02/09/2010 - 5:00pm Type of Content: Article-Research Highlight

Fellow Ralph Jimenez is applying his knowledge of lasers, microscopy, and the precise control of tiny amounts of fluids to the development of a battery-powered blood analyzer for use "off-grid" in Third World countries. He is collaborating with Jeff Squier, David Marr, and their students from the Colorado School of Mines and Charles Eggleton and his student from the University of Maryland,...

Published: 02/09/2008 - 5:00pm Type of Content: Article-Research Highlight

An excellent way to watch proteins fold is to probe the inside of a microfluidics device with light. This tiny device contains micron-sized three-dimensional (3D) transparent channels that carry small amounts of liquid. Inside the channels, the fluid flow is laminar, i.e., there is no turbulence. Consequently, fluid flow through them is predictable and easily modeled. Microfluidics devices...

Published: 09/29/2007 - 6:00pm Type of Content: Article-Research Highlight

Fellows Ralph Jimenez and Henry Kapteyn and their groups recently helped develop optical technology that will make femtosecond laser experiments much simpler to perform, opening the door to using such lasers in many more laboratories.

The technology, which employs reflection grisms as laser pulse compressors, has been patented and is now available commercially. A reflection grism...

Published: 04/08/2006 - 6:00pm Type of Content: Article-Research Highlight

Our lives depend on heme. As part of hemoglobin, it carries oxygen to our tissues. As part of cytochrome c, it helps transform the energy in food into the energy-rich molecule ATP (adenosine triphosphate) that powers biochemical reactions that keep us alive and moving. As part of cytochrome P450, it helps break down toxic chemicals in our bodies.

What is this thing called heme? And...

Published: 03/15/2013 - 12:06pm Type of Content: Biblio
Published: 08/14/2013 - 2:56pm Type of Content: Biblio
Published: 04/27/2016 - 11:24am Type of Content: People - Visiting Fellows
Published: 03/15/2013 - 12:05pm Type of Content: Biblio
Published: 04/26/2016 - 2:28pm Type of Content: People - Visiting Fellows
Published: 04/09/2013 - 3:54pm Type of Content: Biblio
Published: 10/07/2013 - 3:21pm Type of Content: People - Visiting Fellows
Published: 04/22/2015 - 1:39pm Type of Content: Biblio
Published: 03/25/2015 - 5:40pm Type of Content: Biblio
Published: 03/15/2013 - 12:06pm Type of Content: Biblio
Published: 04/11/2014 - 7:57am Type of Content: Biblio
Published: 11/15/2016 - 10:15am Type of Content: Biblio
Published: 03/15/2013 - 12:05pm Type of Content: Biblio
Published: 09/29/2016 - 4:54pm Type of Content: Biblio
Published: 03/15/2013 - 12:05pm Type of Content: Biblio
Published: 04/27/2016 - 10:07am Type of Content: People - Visiting Fellows
Published: 08/13/2015 - 2:56pm Type of Content: Biblio
Published: 04/22/2013 - 12:32pm Type of Content: Biblio
Published: 04/26/2016 - 12:12pm Type of Content: People - Visiting Fellows
Published: 04/29/2015 - 1:42pm Type of Content: Biblio
Published: 10/18/2012 - 2:46pm Type of Content: People - Faculty & Research Groups