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Research Highlights

Published: Fri, 07/21/2017 - 2:45pm

The Perkins group has made dramatic advances in the use of Atomic Force Microscopes (AFMs) to study large single biomolecules, such as proteins and nucleic acids (DNA, RNA), that are important for life. After previously improving AFM measurements of biomolecules by orders of magnitude for stability, sensitivity and time response, the Perkins group has now developed ways to make these precision biomechanical measurements up to 100 times faster than previously possible––obtaining useful information in hours to days rather than weeks to months. 

The Perkins group uses its precision AFM technology to measure the tiny forces and structural states involved in the folding and unfolding of individual molecules of proteins and nucleic acids in their native wet, warm biological environments. How proteins fold and unfold normally––and sometimes misfold are crucial questions to understanding normal physiology and many of the most widespread and devastating diseases, such as cancers, neurodegenerative diseases, and some heart diseases. The Perkins group had already used their AFM technology to reveal new details in...

Published: Oct 31, 2014

New theory describing the spin behavior of ultracold polar molecules is opening the door to...

Published: Oct 14, 2014

Dynamical phase transitions in the quantum world are wildly noisy and chaotic. They don’t look...

Published: Aug 25, 2014

A Be star is a luminous, blue B-type star with distinctive spectral lines that can provide two...

Published: Aug 18, 2014

Symmetries described by SU(N) group theory made it possible for physicists in the 1950s to...

Published: Aug 01, 2014

The Raschke group recently came up with a clever way to detect folds and grain boundaries in...

Published: Jul 13, 2014

The spooky quantum property of entanglement is set to become a powerful tool in precision...

Published: Jun 26, 2014

Graduate student Adam Kaufman and his colleagues in the Regal and Rey groups have demonstrated a...

Published: Jun 22, 2014

The Ye group has not only made two invisible rulers of extreme ultraviolet (XUV) light, but also...

Published: Jun 13, 2014

Imagine a network of multiple clocks orbiting the Earth, not only reporting down to us, but also...

Published: May 27, 2014

Mid-infrared (mid-IR) laser light is accomplishing some remarkable things at JILA. This...

Published: May 22, 2014

Biomolecules may not always behave the same way in test tubes as they do in living cells, a fact...

Published: May 07, 2014

The Markus Raschke group has come up with an innovative way that may one day allow it to peer...

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