Event DetailsEvent Dates: Thursday, October 9, 2014 - 12:00pmSeminar Location: JILA X317Speaker Name(s): Loren HoughSpeaker Affiliation(s): University of Colorado Boulder Seminar Type/SubjectScientific Seminar Type: Condensed Matter SeminarEvent Details & Abstract: Intrinsically disordered protein domains (IDPs) are those which are thought to remain unfolded in a functional form in the cellular environment. Some IDPs act as scaffolds the mediate protein-protein interactions, others serve as regulatory elements, others as polymer brushes prohibiting passage of most macromolecules. However, the function of most IDPs remains unclear. My aim is to use nuclear magnetic resonance and fluorescent techniques to probe the behavior and function of IDPs; in particular how the biophysical properties of IDPs relate to their biological function. I'll give an informal overview of the primary three projects in my lab working towards this goal, which involve proteins involved in nucleo-cytoplasmic transport, cell division and DNA damage repair.