@article{727, author = {E. Potma and D. Jones and J.-X. Cheng and X. Xie and Jun Ye}, title = {High-sensitivity coherent anti-Stokes Raman scattering microscopy with two tightly synchronized picosecond lasers}, abstract = {We demonstrate a significant improvement in signal-to-noise ratio in coherent anti-Stokes Raman scattering (CARS) spectroscopy/microscopy, using two highly synchronized picosecond Ti:sapphire lasers. A temporal jitter between the pulse trains from the two independent commercial lasers is reduced from a few picoseconds to ~21 fs , maintained over several hours. The tight synchronization brings the fluctuation of the CARS signal down to the shot-noise limit, leading to enhanced CARS vibrational images of living cells and polymer beads. © 2002 Optical Society of America}, year = {2002}, journal = {Optics Letters}, volume = {27}, pages = {1168}, month = {2002-07}, issn = {0146-9592}, doi = {10.1364/OL.27.001168}, }